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LAG3/CHO
名稱 LAG3/CHO
型號(hào) CBP74052
報(bào)價(jià)
特點(diǎn) LAG3/CHO，凍存條件：90% FBS+10% DMSO；
  • 詳細(xì)內(nèi)容

LAG3/CHO

CBP74052
I. Background
Lymphocyte-activation gene 3 (LAG3, CD223) is a cell surface protein that belongs to immunoglobulin (Ig) superfamily. LAG3 is expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells. Its main ligand is MHC class II, to which it binds with higher affinity than CD4. It negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1, and has been reported to play a role in Treg suppressive function. A number of LAG3 antibodies are in preclinical development for treatments for cancer and autoimmune disorders. LAG3 may be a better immune checkpoint inhibitor target than CTLA-4 or PD-1 since antibodies to these two checkpoints are only activating effector T cells, and not inhibiting Treg activity where an antagonist LAG3 antibody can both activate effector T cells (by downregulating the LAG3 inhibiting signal) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.

II. Description
Recombinant CHO cells constitutively expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).

III. Introduction
Host Cell:CHO
Expressed gene:LAG3
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):LAG3, LAG-3, CD223
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+400ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Binding Assay,FACS

IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent

Ⅴ. Representative Data

CBP74052.png

Figure Recombinant CHO cells constitutively expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286).



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