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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10401AI-Edigene® EGFR p.L861Q Reference Standard P

AI-Edigene® EGFR p.L861Q Reference Standard P
名稱 AI-Edigene® EGFR p.L861Q Reference Standard P
型號(hào) CBP10401
報(bào)價(jià)
特點(diǎn) AI-Edigene® EGFR p.L861Q Reference Standard Plus
  • 詳細(xì)內(nèi)容

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 CBP10401
FormatGenomic DNA
DescriptionThe L861Q mutation results in an amino acid substitution at position 861 in EGFR, from a leucine (L) to a glutamine (Q). This mutation occurs within exon 21, which encodes part of the kinase domain, and occurs with a frequency of approximately 2% in EGFR-mutated lung tumors (Mitsudomi and Yatabe 2010).
This mutation is associated with increased sensitivity to the EGFR TKIs, erlotinib (Tarceva) and gefitinib (Iressa; Lynch et al. 2004).
  
Technical Data 
DNA Changec.2582T>A
AA Changep.L861Q
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100%
TranscriptENST00000275493
Cosmic IDCOSM6213
Chr position(GRCh37)chr7:55259524
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

10401.png

Storage4℃
Expiry36 months from the date of manufacture

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