名稱 | AI-Edigene® EGFR p.L861Q Reference Standard P |
型號(hào) | CBP10401 |
報(bào)價(jià) | |
特點(diǎn) | AI-Edigene® EGFR p.L861Q Reference Standard Plus |
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電話:4008750250
號(hào)碼:
手機(jī):18066071954
地址:南京市棲霞區(qū)緯地路9號(hào)
Email: zhangxiangwen@cobioer.com
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10401AI-Edigene® EGFR p.L861Q Reference Standard P
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CBP10401 | |
Format | Genomic DNA |
Description | The L861Q mutation results in an amino acid substitution at position 861 in EGFR, from a leucine (L) to a glutamine (Q). This mutation occurs within exon 21, which encodes part of the kinase domain, and occurs with a frequency of approximately 2% in EGFR-mutated lung tumors (Mitsudomi and Yatabe 2010). This mutation is associated with increased sensitivity to the EGFR TKIs, erlotinib (Tarceva) and gefitinib (Iressa; Lynch et al. 2004). |
Technical Data | |
DNA Change | c.2582T>A |
AA Change | p.L861Q |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | ENST00000275493 |
Cosmic ID | COSM6213 |
Chr position(GRCh37) | chr7:55259524 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |