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基因檢測標準品 > Mutation > CBP10509AI-Edigene® FLT3 p.D835V Reference Standard P

AI-Edigene® FLT3 p.D835V Reference Standard P
名稱 AI-Edigene® FLT3 p.D835V Reference Standard P
型號 CBP10509
報價
特點 AI-Edigene® FLT3 p.D835V Reference Standard Plus
  • 詳細內(nèi)容
 CBP10509
FormatGenomic DNA
Description
FLT3 D835V lies within the protein kinase domain activation loop of the Flt3 protein (PMID: 11290608). D835V results in constitutive phosphorylation of Flt3 and activation of Stat5, Erk signaling, leading to transformation of cultured cells (PMID: 15256420), and has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 22504184, PMID: 29187377).
  
Technical Data 
DNA Changec.2504A>T
AA Changep.D835V
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100%
TranscriptNM_004119.3
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

10509.png

Storage4℃
Expiry36 months from the date of manufacture

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