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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74164PD-L1 aAPC Cell IO細(xì)胞株

PD-L1 aAPC Cell IO細(xì)胞株
名稱 PD-L1 aAPC Cell IO細(xì)胞株
型號 CBP74164
報價
特點 PD-L1 aAPC Cell
  • 詳細(xì)內(nèi)容
CBP74164
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
 
II. Introduction
Expressed gene:PDL1
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+1ug/ml puromycin+200ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
 
III. Representative Data

CBP74163、CBP74164 數(shù)據(jù)圖.png

Figure 1. Dose Response of Blocking Antibodies in PD-1/OX40 Dual Effector Reporter Cells (C22) With PD-L1 aAPC Cells.

 

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