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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10423AI-Edigene® BRAF p.V600D Reference Standard P

AI-Edigene® BRAF p.V600D Reference Standard P
名稱 AI-Edigene® BRAF p.V600D Reference Standard P
型號(hào) CBP10423
報(bào)價(jià)
特點(diǎn) AI-Edigene® BRAF p.V600D Reference Standard Plus
  • 詳細(xì)內(nèi)容
 CBP10423
FormatGenomic DNA
Description

BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRaf in cells responding to growth factor signals. Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 600 within the activation segment of B-RAF .

　　
Technical Data　
DNA Changec.1799_1800TG>AT
AA Changep.V600D
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100%
TranscriptENST00000288602
Cosmic IDCOSM477
Chr position(GRCh37)chr7:140453135_140453136
BufferTris-EDTA
　　
Product Information　
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

10423.png

Storage4℃
Expiry36 months from the date of manufacture

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