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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73223EGFR H773_V774insPHPH/BaF3

EGFR H773_V774insPHPH/BaF3
名稱(chēng) EGFR H773_V774insPHPH/BaF3
型號(hào) CBP73223
報(bào)價(jià)
特點(diǎn) EGFR H773_V774insPHPH/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容
CBP73223
I. Introduction

Cell Line Name：

EGFR H773_V774insPHPH/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

EGFR (HER1), epidermal growth factor receptor, is a tyrosine kinase receptor, which activates RAS/RAF/MEK and PI3K/AKT/mTOR pathways, leading to increased cell proliferation and growth (PMID: 24312144). EGFR activating mutations, amplification, and overexpression are found in a variety of tumors, including non-small cell lung cancer (PMID: 26609494, PMID: 30284706) and colorectal cancer (PMID: 30243897), and the EGFRvIII variant is commonly found in glioblastoma (PMID: 30201736).

III. Representative Data

1. WB of EGFR H773_V774insPHPH/BaF3

CBP73223-1.jpg

2. Anti-proliferation assay


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